Pharmaceutical Biolo, " Proanthocyanidins from Ginkgo biloba leaf extract and their radical scavenging activity, Pharmaceutical Biology, 2011 49(5):471-6 " , "",Vol.,No., , , 01/01/2011
:الملخص
Ginkgo biloba L (Ginkgoaceae) is a traditional herbal medicinal plant for the treatment of mild to moderate cognitive disorders, tinnitus, and dementia. These uses may be correlated with the presence of radical scavenging compounds.
The chemical composition and the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the flavan-3-ols and proanthocyanidins from G. biloba were studied.
The compounds have been isolated using column chromatography on Sephadex LH-20 and MCI gel and the structures were determined on the basis of 1D- and 2D-NMR (HSQC, HMBC) experiments of their peracetylated derivatives, MALDI-TOF-MS and by acid-catalyzed degradation with phloroglucinol. The DPPH radical scavenging activities of the compounds were investigated.
The new trimeric prodelphinidin, epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin (compound 7), has been isolated from the air-dried leaves of the title plant, in addition to catechin, epigallocatechin, gallocatechin, and three dimeric proanthocyanidins. The dimeric prodelphinidin epigallocatechin-(4β→8)-epigallocatechin (compound 6) showed the strongest DPPH radical scavenging activity, with IC(50) 1.7 μg/mL, 10 times more active than the positive control, BHT (IC(50) 17.3 µg/mL), followed by the new trimeric proanthocyanidin epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin with IC(50) 2.1 µg/mL. The crude extract exhibited high DPPH radical scavenging activity with IC(50) 15.5 µg/mL comparable with that of BHT.
The results showed that all the isolated compounds from the tannin fraction exhibited potent free radical scavenging activities, which were higher than that of BHT, suggesting that the condensed tannins from G. biloba leaves strongly contribute to the overall antioxidant effects.
Scientica Pharmaceut, " Polyphenols from Ginkgo biloba leaf extract, Scientica Pharmaceutica, 2010 28;78(4):897-907 " , "",Vol.,No., , , 01/01/2010
:الملخص
By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted to acidic depolymerization in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D-and reverse 2D-NMR (HSQC, HMBC) spectra of their peracetylated derivatives, MALDI-TOF-MS and CD-spectroscopy. The observations resulting from the degradation with phloroglucinol were confirmed by 13C-NMR spectroscopy of the polymer. The mean molecular weight of the polymeric fraction was estimated to be 9–10 flavan-3-ol-units.
Natural Product Rese, " Antioxidant oligomeric proanthocyanidins from Cistus salvifolius, Natural Product Research, 2006 20 (13):1216-24 " , "",Vol.,No., , , 01/01/2006
:الملخص
The purified proanthocyanidin oligomers of Cistus salvifolius herb extract accounted for 78% of the total proanthocyanidins and 73% of the total antioxidant activity of this extract. To elucidate the structure of the oligomer, it was depolymerized by acid catalysis in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D- and reverse 2D-NMR (HSQC, HMBC) experiments of their peracetylated derivatives, MALDI-TOF-MS and CD spectroscopy. These observations resulting from the degradation with phloroglucinol were confirmed by 13C NMR spectroscopy of the oligomer. The mean molecular weight of the higher oligomeric fraction was estimated to be 5–6 flavan-3-ol-units.
Kenza Mansoor, Fadi Qadan, Mathias Schmidt, " Hamamelis virginiana L. leaf extract suppositories in the treatment of hemorrhoids: Non-interventional trial and stability study. " , " Pharmazie",Vol.0,No., Eschborn : Govi-Verlag Pharmazautischer Verlag, Amman, 04/01/2018
:الملخص
Objective: The effectiveness of suppositories containing witch-hazel leaf extract (Hamamelis virginiana L.) and menthol in the treatment of hemorrhoids was assessed in a non-interventional clinical study. The stability of the test preparation was ensured through a formal accelerated stability study.
K Mansoor, F Qadan, M Schmidt, E Mallah, W Abudayyih, K Matalka. , " 2. Stability study and a 14-day oral dose toxicity in rats of plantain leaf extract (Plantago lanceolata L.) syrup. " , "Scientia Pharmaceutica",Vol.,No., Multidisciplinary Digital Publishing Institute, , 03/22/2017
:الملخص
Plants have been used since antiquity to treat and prevent diseases. Plantain (Plantago lanceolata L.) is traditionally used for the treatment of the common cold and associated symptoms such as cough. This study was designed to evaluate the oral toxicity of plantain leaf extract-containing syrup. In
. KA Mansoor, KZ Matalka, FS Qa’dan, R Awad, M Schmidt, " Two new proanthocyanidin trimers isolated from Cistus incanus L. demonstrate potent anti-inflammatory activity and selectivity to cyclooxygenase isoenzymes inhibition. " , "Natural Product Research",Vol.,No., Milton Park, UK : Taylor & Francis Health Sciences, , 09/01/2016
:الملخص
Two new proanthocyanidin trimers have been isolated from Cistus incanus herb; gallocatechin-(4α→6)-gallocatechin-(4α→8)-gallocatechin (compound 1) and epigallocatechin-3-O-gallate-(4ß→8)-epigallocatechin-3-O-gallate-(4ß→8)-gallocatechin (compound 2). The structures were determined on the basis of 1D
AN Zaid, MN Abualhasan, N Jaradat, M Marar, K Mansoor, F Qa’dan, " 4. Development and validation of a new analytical HPLC method for the estimation of carvone in suppositories. " , "Journal of Pharmaceutical Investigation",Vol.,No., Springer Netherlands, , 10/01/2016
:الملخص
Carvone volatile oil is a commercial product that is widely used in the food, cosmetic and pharmaceutical industry due to its fragrance, flavoring and medicinal properties. A validated HPLC method for the qualitative and quantitative analysis of this oil in raw and commercial products is not availab
KZ Matalka, NA Abdulridha, MM Badr, K Mansoor, NA Qinna, F Qadan, " 5. Eriobotrya japonica water extract characterization: an inducer of interferon-gamma production mainly by the JAK-STAT pathway. " , "Molecules",Vol.,No., Basel, Switzerland : MDPI, , 06/01/2016
:الملخص
Eriobotrya japonica (Thunb.) Lindl.(Loquat)(EJ) has been used as a medicinal plant to treat chronic bronchitis, coughs, phlegm, high fever and gastro-enteric disorders. Since the traditional use of EJ is related to modulating inflammation processes, our earlier studies on EJ leaves were performed on
