جامعة البترا | التفاصيل

الرئيسية

التفاصيل

التقويم

الإسم : فيصل العكايلة

الرتبة العلمية: أستاذ مشارك

المسمى الوظيفي: رئيس قسم

المكتب 8303 الرقم الفرعي 537

بريد الكتروني: falakayleh@uop.edu.jo

التخصص: صيدلانيات

جامعة التخرج: جامعة بغداد

أيار 2022

السبت

الأحد

الإثنين

الثلاثاء

الأربعاء

الخميس

الجمعة

الروابط الهامة

الأخبار

عرض الكل

Journal Paper

Rana Al-Shaikh Hamid, " Evaluation of Three Chitin Metal Silicate Co-precipitates as a Potential Multifunctional Single Excipient in Tablet Formulations " , "Marine Drugs",Vol.8,No.1660-3397, , , 10/25/2010

:الملخص

The performance of the novel chitin metal silicate (CMS) co-precipitates as a single multifunctional excipient in tablet formulation using direct compression and wet granulation methods is evaluated. The neutral, acidic, and basic drugs Spironolactone (SPL), ibuprofen (IBU) and metronidazole (MET), respectively, were used as model drugs. Commercial Aldactone®, Fleximex® and Dumazole® tablets containing SPL, IBU and MET, respectively, and tablets made using Avicel® 200, were used in the study for comparison purposes. Tablets of acceptable crushing strength (>40 N) were obtained using CMS. The friability values for all tablets were well below the maximum 1% USP tolerance limit. CMS produced superdisintegrating tablets (disintegration time < 1 min) with the three model drugs. Regarding the dissolution rate, the sequence was as follow: CMS > Fleximex® > Avicel® 200, CMS > Avicel® 200 > Dumazole® and Aldactone® > Avicel® 200 > CMS for IBU, MET and SPL, respectively. Compressional properties of formulations were analyzed using density measurements and the compression Kawakita equation as assessment parameters. On the basis of DSC results, CMS co precipitates were found to be compatible with the tested drugs. Conclusively, the CMS co-precipitates have OPEN ACCESS Mar. Drugs 2010, 8 1700 the potential to be used as filler, binder, and superdisintegrant, all-in-one, in the design of tablets by the direct compression as well as wet granulation methods.

Faisal Al-Akayleh, M, " Formulation and In vitro assessment of sustained release terbutaline sulfate tablet made from binary hydrophilic polymer mixtures. " , "Pharmaceutical Development and Technology",Vol.4,No.5, Informa Healthcare, London, 10/06/2011

:الملخص

In the present systematic study, a sustained release of terbutaline sulfate tablet (TBS) was developed and optimized by employing the hydrophilic polymers; chitosan and xanthan gum mixed with sodium bicarbonate as a release modifying agent. This formulation was developed using direct compression technology. In vitro release studies indicated rapid swelling and drug release in the initial period of the acid stage from a matrix composed of chitosan and xanthan gum solely. Addition of sodium bicarbonate to the matrix resulted in sustained drug release. Various formulation factors such as polymer to polymer ratio, polymer viscosity and particle size were altered and their effect on dissolution pattern was illustrated. Manufacturing variables such as compression force and lubricant percentage were investigated and found not to influence the drug release profile of the resulted tablets. The release mechanism follows Korsmeyer-Peppas equation with n value indicating non-Fickian diffusion. The release profiles were analyzed using statistical method (one-way ANOVA) and f(2) metric values and found to be similar to the commercial product Bricanyl(®). Reproducible data were obtained when scale-up of the formulation was performed.

Faisal Alakayleh, Iyad Rashid, Mahmoud Al-Omari, Khaldoun Al-Sou, " compression profiles of different molecular weight chitosans " , "Powder Technology",Vol.,No., Elsiver, , 05/14/2016

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F. Al-Akayleh * 1, Z. Zakari, S. Adwan 2 and M. Al-Remawi 1, " PREPARATION, CHARACTERIZATION AND EX-VIVO HUMAN SKIN PERMEATION OF IBUPROFEN-SOLUPLUS POLYMERIC NANOMICELLES " , "international journal of pharmaceutical sciences and research",Vol.12,No., https://ijpsr.com/articles/?order=cited, india, 06/08/2021

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Master Thesis

Rana Al-Shaikh Hame, " EVALUATION OF CHITIN METAL SILICATE CO PRECIPITATES AS POTENTIAL MULTIFUNCTIONAL EXCIPIENTS IN TABLET FORMULATIONS " , "",Vol.,No., , , 06/15/2010

Ruaa Al-Ajeeli, Dr. , " Formulation and in Vitro/ in Vivo Evaluation of In-Situ Gel Matrix System for Sustaining the Release of Paractamol " , "",Vol.,No., , , 01/15/2010

المؤهل العلمي

المؤهل العلمي	الجامعة	البلد	سنة الحصول على المؤهل
البكالوريوس	الجامعة الاردنية	الاردن	1994
الماجستير	بغداد	العراق	1998
الدكتوراه	جامعة بغداد	العراق	2004