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الإسم : وائل أبو دية

الرتبة العلمية: أستاذ دكتور

المسمى الوظيفي: رئيس قسم

المكتب 8119       الرقم الفرعي 8119

بريد الكتروني: wabudayyih@uop.edu.jo

التخصص: تحاليل صيدلانيه

جامعة التخرج: جامعة مولدوفا الحكومية

تحميل السيرة الذاتية

المؤهل العلمي

    المؤهل العلمي

    الجامعة

    البلد

    سنة الحصول على المؤهل

    البكالوريوس
    جامعة الطب والصيدلة /كلوج - نابوكا
    رومانيا
    1993
    الماجستير
    جامعة كلوج - نابوكا للطب والصيدلة
    رومانيا
    1993
    الدكتوراه
    جامعة مولدوفا الحكومية
    مولدوفا
    2002



  • Book





      Wael Abu Dayyih&Coll, " Storage and Drug Keeping " , "",Vol.,No., , , 10/25/2010 :الملخص
      this handbook is intended to serve fundamentals of storage and drug keeping for pharmacists and pharmacy technician who works either in drug company warehouse or drug stores or private pharmacies




      Wael Abu Dayyih&Coll, " Toxicology and Antidote " , "",Vol.,No., , , 10/25/2010 :الملخص
      the needs of the pharmacists and other medical professions to find a solution for any poisoning problem and antidotes




      Dr. Wael Abu Dayyih , " Pharmacology Text Book " , "",Vol.,No., دار الثقافة, amman, 10/25/2010 :الملخص
      this book is intended to serve as an introductory to the pharmacists and other medical profession




      Wael Abu Dayyih.Eyad, " Main Concepts in Quantitative Analysis " , "Main Concepts in Quantitative Analysis",Vol.,No., Darkonoz, Amman,Jordan, 04/02/2012 :الملخص
      Analytical chemistry continues to be taught in a variety of was at different schools. Courses are found at every level from the freshman to the senior year. Some are for chemistry majors; others are service courses for students in such fields as agriculture, biology, engineering, and medical technology. No single book can be optimized for all of these, nor can it accommodate the viewpoints of every teacher. Nevertheless we have tried to keep the book useful for several types of courses by avoiding extremes, writing clearly and carefully, making chapters (or small groups of chapters) as independent as possible, and utilizing experience with earlier editions".




      Wael Abu Dayyih, Eya, " Main Concepts in Quantitative Analysis - Analytical Chemistry " , "",Vol.,No., Dar Konoz, Amman, Jordan, 10/14/2014


  • Journal Paper





      , " Nitrate selective electrode based on the trinuclear chromium (III) bivalent. " , "",Vol.,No., , , 03/13/2008 :الملخص
      Mihail Revenco, Mariana Martin, Wael Abu Dayyih Chemistry Journal of Moldova 3(1)44-47, 2008




      , " Synthesis and structure of a new heterpolytungstate with central vanadium (IV) atom " , "",Vol.,No., , , 09/02/2003 :الملخص
      Revenco M.D, Petrenko P.A, Kozelenco A.A, Simonov Yu.A, Wael Abu Dayyih, Lipkowski J, Grosu P.N Synthesis and structure of a new heterpolytungstate with central vanadium (IV) atom. Russian Journal of Inorganic Chemistry, ISSN 0036-0236 /vol.48 n3 p.322-329.Editure Springer, New York NY Etats –Unis2003




      M.Revenco,Martin M.,, " Thiocynate ion-selective PVC membrane electrode " , "Chem.J .Mold.",Vol.5,No.(1), , Moldova, 05/01/2010 :الملخص
      Abstract A potentiometric selective sensor based on trinuclear chromium(III) complex as a novel ionophore for the thiocyanate-selective electrode is reported. The sensor displays a near Nernstian slope of 57 ± 2 mV per decade, over a wide pH range 3 - 11. The working concentration range of the electrode is 1.10-5 – 1.10-1 mol/L with a detection limit of 5.10-6 mol/L. The sensor has a response time of 20 s and can be used for at least 6 months without any considerable fl uctuation of the potential. The selectivity coeffi cients determined at using the fi xed interference method indicate a good discriminating ability towards other anions. The prepared sensor was applied as an indicator electrode in the titration of thiocyanate with Ag+.




      Eyad Mallah, Qutaiba, " ,"Crystal structure of trimethylsulfoxonium phthalimide, [C3H9SO][C8H4NO2], " " , "" Z. Kristallogr NCS",Vol.vol. 226,No.pp.345 , , Germany, 11/06/2011 :الملخص
      Eyad Mallah, Qutaiba Abu-Salem, Wael Abu Dayyih, Mohammed Hamad, Manfred Steimann and Caecilia Maichle-Mössmer,"Crystal structure of trimethylsulfoxonium phthalimide, [C3H9SO][C8H4NO2], " Z. Kristallogr. NCS,vol. 226, Germany, 6/17/2011, pp.345 - Click To view>> Abstract




      E. Mallah, K. Sweida, " 2-Bromo-1,3-diisopropyl-4,5-dimethyl-1H-imidazol-3-ium dicyanidoargentate " , "Acta Crystallographica",Vol.Volume 68,No.Part 1, Acta Cryst. 2012, , 12/01/2011 :الملخص
      Acta Cryst. (2012). E68, m17 [ doi:10.1107/S1600536811051828 ] 2-Bromo-1,3-diisopropyl-4,5-dimethyl-1H-imidazol-3-ium dicyanidoargentate E. Mallah, K. Sweidan, Q. Abu-Salem, W. Abu Dayyih and M. Steimann Abstract: The title structure, (C11H20BrN2)[Ag(CN)2)], is built up from an approximately C2v-symmetric imidazolium cation and a nearly linear dicyanidoargentate anion [N-Ag-N = 176.6 (9)° and Ag-C-N = 178.8 (9) and 177.2 (11)°]. These two constituents are linked by a remarkably short interaction between the Br atom of the imidazolium cation [C-Br = 1.85 (3) Å] and one N atom of the cyanidoargentate anion [BrN = 2.96 (2) Å], which is much less than the sum of the van der Waals radii (3.40 Å). The crystal studied was twinned by merohedry




      Wael Abu Dayyih, Ahm, " Simultaneous High performance liquid chromatographic analysis of Oxicams in pharmaceutical formulations " , "Int J Pharm",Vol.2(4),No.2(4), Pharmascholar, , 10/01/2012 :الملخص
      ABSTRACT A highly sensitive, accurate and rapid HPLC analytical method for the determination of Tenoxicam (TEN), Piroxicam (PIR) and Meloxicam (MEL) in a finished dosage form was developed and validated. C18 reversed phase column was used. The mobile phase was composed of methanol and aqueous buffer solution (disodium hydrogen phosphate dihydrate mixed with citric acid) (60:40),at pH of 5.8. The flow rate was 1.2 ml/min and the applied analytical wavelength was 360 nm. The calibration curve was linear over the range 1.010- 3.030, 1.513-4.538 and 1.765-5.295 mg/L for TEN, PIR and MEL, respectively. The lower limit of detection and the lower limit of quantification for TEN were 0.06 and 0.18 mg/L, while they were 0.09 and 0.28 mg/L, for PIR, and 0.12 and 0.38 mg/L, respectively for MEL. The peaks resolution was tested under several conditions and found that 5% increase of organic mixture or a 0.5 increase in the pH buffer would decrease the peak resolution between PIR and MEL. In conclusion, such method may successfully replace the classical analytical methods of Oxicams. Download




      Khalid Z. Matalka, F, " Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations " , " International Journal of Immunopharmacology",Vol.14,No.3, elservier, , 10/11/2012 :الملخص
      Abstract We recently designed a series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds, called ZM compounds. These ZM compounds were categorized according to the nature of the cyclic amino groups into ZM2, ZM3, ZM4, and ZM5 and were shown to reduce carrageenan-induced inflammation, inhibit cyclooxygenase (1 and 2) and have less adverse effects than the common non-steroidal anti-inflammatory drugs. In the present study, we are examining the potential effects of ZM compounds in modulating cytokines production in vivo and in vitro from stimulated spleen cells, CD4+ CD25+ ve T regulatory cells and CD4 + CD25− ve T helper cells. Six hours following oral administration of 20 mg/kg of ZM4 and ZM5 compounds reversed LPS-induced TGF-β suppression whereas ZM2, ZM3, ZM4, and ZM5 reversed LPS-induced TNF-α and IL-12 increase in mice spleen. In addition, increasing concentrations of ZM2, ZM4 and ZM5 increased significantly TGF-β1 production, whereas ZM3, ZM4 and ZM5 suppressed only TNF-α production in LPS and LPS + PMA stimulated spleen cells. Furthermore, only ZM5, enhanced significantly TGF-β1 production from LPS and LPS + PMA stimulated CD4 + CD25+ve cells (p < 0.001), whereas none of the ZM compounds modulated TNF-α from CD4 + CD25− ve T helper cells. These results indicate that ZM5 (N-{4-(2-Azepan-1-yl)-but-2-yn-1-yl}isoindoline-1,3-dione) enhances TGF-β production from CD4 + CD25+ ve cells independent of protein kinase C activation and suggest that all ZM compounds suppress TNF-α from monocytes/macrophage cells. In conclusion, these ZM compounds have potential to be used use as anti-inflammatory agents and further studies to show the possibility of utilizing these basic aminoacetylenic isoindolines in autoimmune mediated inflammatory diseases are warranted. Download




      Wael Abu Dayyih, Noo, " Development and validation of HPLC method for some Azoles in pharmaceutical preparation " , "Int J Pharm Sci Res",Vol.Vol. 3,,No.Issue 10, Society of Pharmaceutical Sciences & Research, , 10/02/2012 :الملخص
      A new, simple and rapid reversed-phase high-performance liquid chromatography (HPLC) method was developed and validated for the determination of some azoles drug (Ketoconazole, Isoconazole and Miconazole) in pharmaceutical dosage forms in Jordan market. The HPLC separation was achieved on a C18 BDS column (100 mm × 4.6 mm) using a mobile phase of acetonitrile and 0.05 M Ammonium Acetate buffer (70:30, v/v) that adjusted to pH 6 using phosphoric acid at a flow rate of 1 mL min−1 and using UV absorbance detection at 254 nm. The method was validated for specificity, linearity, precision, accuracy, robustness. The separation was completed within 11.77 minutes and the assay was linear over the concentration range of 50% to 150% (r2 = 0.9999), the percent recovery for test and reference formulation was (98.14%-101.12%). Download




      Wael Abu Dayyih, Sar, " Development and validation of reverse HPLC method for simultaneous estimation of some Prills in drug forms " , "Int J Pharm Pharm Sci",Vol.5,No.1, Academic Science, , 01/01/2013 :الملخص
      A simple, economical, precise, accurate, and rapid HPLC method has been developed and validated for assay determination of Captopril, Lisinopril and Imidapril simultaneously in their raw material and tablet dosage form. The chromatographic condition was performed on a mixture of Acetonitrile and phosphate buffer (25:75 v/v) ratio. The detection of Prills drugs was carried out at 210 nm with a flow rate of 1.0 ml/min. The retention time (min) for Lisinopril, Captopril and Imidapril were 3.6, 4.4, and 7.4 min respectively. Results of the analysis were validated statistically, and by recovery studies. The proposed method was successfully employed for the estimation of the drug contents in marketed formulation, according to ICH guidelines and found to be satisfactory Download




      Khalid Z Matalka, Ma, " Enhancing Doxorubicin-Induced MCA-Fibrosarcoma Cytotoxicity by an Eriobotrya japonica Hydrophilic Butanol-Treated Extract through Natural Killer Cells Activation " , "J Cancer Sci Ther",Vol.,No.sp.issue 18, , , 12/14/2012 :الملخص
      The combination of cytotoxic drugs with immunotherapy should be more effective than monotherapy alone since both therapeutic modalities may target different mechanisms. In addition, combination therapy may reduce adverse events associated with cytotoxic drugs. Eriobotrya japonica hydrophilic butanol-treated extract (EJWR) was found to modulate cytokines by enhancing IL-12, IFN-γ and TNF-α in vitro and in vivo and within tumor microenvironment. This was associated with enhancing survival time of mice bearing intra-peritoneal MCA fibrosarcoma (MCA FS). In the present work, we evaluated the combination of EJWR with doxorubicin (Dox) on MCA FS cytotoxicity using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay in the absence and presence of spleen cells or Natural Killer (NK) lymphocytes from tumor bearing mice. The results showed that Dox exhibited mild cytotoxicity to healthy spleen cells and EJWR reversed such cytotoxicity. In addition, increasing concentrations of Dox induced 40% (p<0.01) MCA FS cytotoxicity. This percent increased significantly to 60% at Dox 5 μM when co-cultured with NK cells from tumor bearing mice and increased further to 80% (p<0.01) when Dox was combined with EJWR. The latter increase in cytotoxicity was significantly (p<0.01) higher than each agent alone. This enhancement was associated with significant production of TNF-α and retaining IFN-γ levels from NK cells lysates. This concluded that the immunomodulator, EJWR, mediates NK activation and enhances Dox- induced MCA FS cytotoxicity. Download




      Wael Abu Dayyih*, Ey, " Crystal structure of 1,3-diisopropyl-4,5-dimethylimidazolium oxalic acid monomethyl ester, C14H24N2O4 " , "Z. Kristallogr. NCS",Vol.228 (2013),No., Oldenbourg Wissenschaftsverlag, München,Germany, 01/18/2013 :الملخص
      Abstract C14H24N2O4, monoclinic, P21/n (no. 14), a = 8.1862(8) Å, b = 10.313(1) Å, c = 18.534(2) Å, b = 101.018(8)°, V = 1535.8 Å3, Z = 4, Rgt(F) = 0.0567, wRref(F2) = 0.1064, T = 173 K. Download




      Wael A. ABU DAYYIH ,, " A Stability-Indicating High Performance Liquid Chromatographic (HPLC) Assay for the Determination of Cefaclor in Biological Fluid " , "Latin American Journal of Pharmacy",Vol.32,No.4, College of Pharmacists of Buenos Aires , Argentina, 05/10/2013 :الملخص
      While determining cefaclor in biological fluid, it could be degraded due to oxidation hydrolysis and racemisation. Furthermore, such degradation process can be accelerated depending on pH, temperature, carbon dioxide, oxygen, light, humidity and storage. Thus such measures are crucial in cefaclor determination in biological fluids and reducing or inhibiting the degradation process while assaying is mandatory. In the developed method, samples were assayed without pretreatment or with perchloric acid and protein precipitation treatment. Sulphamethoxazole as an internal standard was used. Chromatographic separation was carried out on with lichrospher RP-18 column using mobile phase 80:20 v/v (potassium dihydrogen phosphate buffer (0.067M): methanol, pH 4.5), hexane-1-sulphonic acid sodium salt (0.002 M) was used as an ion pair and the flow rate was 1.3 mL/min. Cefaclor was monitored using UV detector at λ 265 nm. Pre-sample treatment with perchloric acid as acidifying agent and plasma protein precipitant was found to enhance stability of cefaclor. The calibration curve was demonstrated to be linear in the range of 0.25-20 μg/mL (r2 = 0.999) and the limit of quantitation was estimated at 0.25 μg/mL. In conclusion, a stability-indicating, accurate, precise, simple, and highly sensitive reversed phase HPLC method for the determination of cefaclor in biological fluids was developed and can be successfully used in bioequivalence study and other pharmacokinetic evaluation. Download




      Wael Abu Dayyih , En, " Development and Validation of a Stability–Indicating HPLC Method for Determination of Bupivacaine in Human Plasma " , "Int.J.of Pharmaceutical Analysis",Vol.38,No.2, Recent Science, Uk, 09/30/2013 :الملخص
      ABSTRACT The purpose of the research described herein was to develop and validate a stability indicating HPLC method for determination of Bupivacaine in human plasma .A simple, rapid, accurate, and precise gradient reversedphase (RP-HPLC) method has been developed for the determination of Bupivacaine in human plasma. BDS Hypersil C18 Column (150mm x 4.6mm, 5μm, Thermo Electron Corp. using 66.5 % water, 33.5 % Acetonitrile, 1 ml/L Triethylamine, pH = 2.5,as mobile phase at a flow rate of 1.0 ml/min. UV Detector λ = 202 nm. at column temperature (40°C). Retention times dependent upon HPLC conditions which, 3.1 – 3.3 minutes Bisoprolol as (Internal Standard) and 3.5 – 3.7 minutes for the Bupivacaine the correlation coefficient was 0.99930which represent a linearity strength of this method . The proposed method was further applied to the determination of Bupivacaine in human plasma, with good percent recovery. The accuracy and the precision of the method were validated on intraday and interday basis in accordance with ICH guidelines Download




      Riad Awad ,Hana Hama, " Quality Control of Cinnamic Acid in Traditional Medicinal Plants in Jordan using High Performance Liquid Chromatography " , "IJPPS(Int J Pharm Pharm Sci)",Vol.6,No.4, Academic Sciences, UK, India, 05/02/2014 :الملخص
      ABSTRACT Objective of the study is the analysis of cinnamic acid from commercial herbal drugs, and from dried plant material used in traditional medicine in Jordan market qualitatively and quantitatively by using high performance liquid chromatography. Methods: The chromatographic conditions comprised of a reversed-phase RP-8 column with a mobile phase consisting of a mixture of Acetonitrile: Phosphate buffer solution (35:65 v/v) with flow rate 1 ml/min. The detection was carried out at 269 nm, with retention time of 17.3 min. The standard curve was linear over the range of (20-400) µg/ml with correlation coefficient of the linear calibration graphs for the analytics exceeded (0.9987). Result: A Simple, sensitive and specific HPLC method was developed and validated for a qualitative and quantitative analysis of cinnamic acid from commercial herbal drugs, and from dried plant material used in traditional medicine in Jordan market. Conclusion: The highest concentration of cinnamic acid was found in Cinnamon verum(Lauraceous) (4330 µg/g) while the other plants contain insignificant amount of cinnamic acid as it is a key intermediate precursor for many plant metabolites. The cinnamic acid and derivates were successfully separated using pH 2.5.The developed method was successfully applied to estimate the amount of cinnamic acid in the main traditional medicinal plants in Jordan market. KEY WORDS: Cinnamic Acid, , Cinnamon, Sumac, Cranberry, Artichoke, Bay Laurel, Mango leaves, HPLC, Validation Download




      Dana A Darwish, Suza, " Awareness of antibiotic use and antimicrobial resistance in the Iraqi community in Jordan " , "The Journal of Infection in Developing Countries",Vol.8,No.05, , , 05/01/2014 :الملخص
      Abstract Introduction: Antimicrobial resistance is a serious global health concern. It has considerable implications on societies' health and resources. In Jordan, there is a large Iraqi community due to the ongoing turmoil in Iraq. Unfortunately, health awareness and practices of this community are under-investigated due to scarcity of research. This paper assesses the awareness of antibiotic use and antimicrobial resistance in the Iraqi community residing in Amman, Jordan. Their level of interaction with health care professionals regarding antibiotics and differences in their antibiotic use between Iraq and Jordan are also discussed. Methodology: A cross-sectional questionnaire-based survey involving randomly selected Iraqis residing in Amman, Jordan was conducted. Results: The study involved 508 participants. Sixty-two percent of participants agreed with buying antibiotics without a prescription, 29% agreed with obtaining antibiotics from friends or relatives, and 46% agreed with keeping leftover antibiotics for future use. Furthermore, 60% disagreed with not completing an antibiotic course and almost 90% of the sample listed viral diseases as an indication for antibiotics. Forty-four percent of participants abided by physicians’ instructions on antibiotic use. Half of the participants believed that pharmacists provided instructions on antibiotics all the time, whereas physicians were perceived to do so by 29% of participants. Conclusions: Gaps exist in knowledge of antibiotic use and reasons for antimicrobial resistance among Iraqis residing in Jordan. These gaps should serve in planning educational campaigns to raise the community’s awareness of responsible antibiotic use. Law enforcement to restrict access to antibiotics is also pivotal to tackle their misuse. Keywords awareness; antibiotics; antimicrobial resistance; Iraqi; Jordan Download




      Haifa T. Abu Tbeekh, " Pomegranate Juice Affects on Pharmacokinetic Parameters of Metronidazole by Using HPLC-MS " , "WJPPS",Vol.3,No.7, , Bulgaria, 07/01/2014 :الملخص
      Objective: To quantify Metronidazole in rat serum by using HPLC/MS and to study the effect of pomegranate fresh juice on the Metronidazole pharmacokinetics Methods: The serum samples were prepared by using protein precipitation method with Clindamycin in methanol solution. A gradient mobile phase system and ACE 5 C18 column were used for the analysis. Rats (n=4) were treated with a single ordinary dose (5ml/kg) of freshly squeezed pomegranate juice 30 min before orally administered-Metronidazole while other groups of rats (n=4) were treated with a multiple dose of the juice twice daily for two days versus DW pretreated rats (n=2). The study protocol was approved by the ethical committee of Graduate Studies at Faculty of Pharmacy and Medical Sciences of University of Petra/Amman-Jordan (March, 2012). Key findings: The analytical method was linear with acceptable recovery, precision and accuracy. The results show that there was a significant increase in the Metronidazole pharmacokinetic parameters (Cmax and AUC, P<0.05) after pretreatment with multiple dose of pomegranate juice. Conclusions: Pomegranate juice with a multiple dose pre-treatment could be a good intestinal but not hepatic enzymes inhibitor for Metronidazole metabolism. KEYWORDS: Pomegranate, Metronidazole, Pharmacokinetic, HPLC/MS. Download




      Riad Awad, Eyad Mall, " Bis(methyl­sulfon­yl)methane compound, C3H8O4S2, the two central S—C(H2) " , "Acta Crystallographica Section E ",Vol.70,No.8, , Germany, 07/30/2014 :الملخص
      In the title compound, C3H8O4S2, the two central S—C(H2) bond lengths are almost identical [1.781 (2) and 1.789 (2) Å]. In the crystal, each mol­ecule utilizes CH2 and CH3 bonds to form weak C—H⋯O hydrogen bonds to six other mol­ecules, thus linking mol­ecules into a three-dimensional network. Download




      Wael Abu Dayyih,Dani, " Pethidine Level in Jordanian Women and their Newborns during Labor after a Single Intravenous Dose " , "International Journal of Clinical Anesthiosiology",Vol.2,No.3, JSciMed Center, California , USA, 10/15/2014 :الملخص
      Background: Since 1940, pethidine became the most widely used opioid for labor analgesia. However, pethidine administration may cause fetal distress especially if delivery occurred in a short time after administration and due to genetic variations between populations. Therefore,the aim of this study was to develop a validated and sensitive method for determination of pethidine in plasmafollowed by determination of plasma pethidine level in Jordanian women at different times duringand after labor and in the neonatal cord just after delivery. Methods: Liquid Chromatography tandem mass spectrometry was developed to measure pethidine levels in plasma. Fifteen pregnant females agreed to enroll in the study and each signed an informed consent. All pregnant females received a single intravenous dose of 50 mg pethidine followed by withdrawing of blood samples at certain time points for the measurement of pethidine levels. In addition, umbilical cord was collected for the same purpose. Results: Due to fetal distress, three out of fifteen subjects (20%) dropped out of the study following pethidine administration and went through Caesarian section. Two of the three withdrawn cases had high maternal pethidine plasma levels. A negative correlation was found between pethidine bioavailability in the newborn and the dose-delivery duration (p<0.01). Conclusion: The present study showed that single intravenous dose during labor cannot be considered safe in Jordanian population without an extensive study with larger sample size regarding pethidine route of administration and its metabolism. In addition, there was a negative correlation between maternal’s pethidine concentration and Apgar score (p<0.05). Download




      Eyad Mallah, Kamal S, " Crystal structure of 1,3-dicyclohexyl-4,5-dimethyl-1Himidazol-3-ium-2-carbodithioate chloroform monosolvate " , "Acta Cryst.E",Vol.E70,No., IUCr Journals, Germany, 11/05/2014 :الملخص
      The title compound, C18H28N2S2CHCl3, crystallizes as a zwitterion. The C—S bonds are almost equivalent, with lengths of 1.666 (3) and 1.657 (3) A˚ . The S—C—S bond angle is expanded to 129.54 (16) and the N—C—N angle is reduced to the tetrahedal value of 108.8 (2). In the crystal, adjacent molecules are linked via C—HS hydrogen bonds, forming chains along [100]. The chloroform solvent molecule, which is disordered over two positions [occupancy ratio = 0.51 (2):0.49 (2)], is linked to the chain by bifurcated C— H(S,S) hydrogen bonds. Keywords: crystal structure; imidazole; carbodithioate; zwitterion. CCDC re Download




      Wael Abu Dayyih, Ala, " Simultaneous determination of Atorvastatin, Glimepiride and Amlodipine in solution and plasma matrix using HPLC/UV method " , "Journal of Chemical and Pharmaceutical Research,",Vol.6,No.11, , USA, 12/01/2014 :الملخص
      The aim was to develop and validate a simple, fast, reliable, selective and accurate HPLC method with UV detection for simultaneous determination of atorvastatin, glimepiride and amlodipine in a solution and plasma matrix. The method consisted of a mobile phase containing water, methanol and acetonitrile at 1.58:1:1(v/v%) buffered with triethylamine at pH8.0, a flow rate of 1.5 ml/min and a UV detector at 237 nm wavelength. Different and slight variations were introduced in the mobile phase, pH, wavelength, and column temperature to ensure method robustness in yielding good accuracy and precision. Other parameters such as sunlight sample exposure and acid degradation were evaluated on solutions containing the three drugs. A successful HPLC method was validated and developed to detect and quantify atorvastatin, glimepiride and amlodipine in a solution and plasma matrix, system and method precision were reasonable as RSD% values were below 2%, calibration curves revealed linearity in the range of 0.5-1.5 μg/ml for all the three drugs dissolved in the diluent with R2>0.99. RSD% in the linear range and for each of the calibration curve is between 0.03-0.32 for amlodipine, 0.03-0.36 for glimepiride and 0.18-0.46 for atorvastatin. Accuracy was with %recovery for each drug concentration between 98-102% which was considered as acceptable according to USP guidelines for analytical method validation. Stability tests represented reasonable stability of method for three drugs in both plasma and solutions as the % recovery was between 98-102%. Robustness was reliable as wavelength variation,pH variation, acid /base degradation, temperature changes and acetonitrile change in mobile phase showed RSD% less than 2% for all. The method was selective for the three drugs without any possible interference between excipients present in a tablet and the three drugs. Results indicated the method suitability to be used for determination of amlodipine, glimepiride and atorvastatin simultaneously in two different matrices, diluent and plasma. Key words: Atorvastatin, Glimepiride, Amlodipine, HPLC, Solution, Plasma. Download




      Eyad Mallah, Nibras , " Simultaneous Determination of Sildenafil and Glimepiride in Rat Plasma by Using Lc-Ms Method and their Applications in Pharmacokinetic Interactions " , "JSM Clinical Pharmaceutics",Vol.1,No.2, Sci Med Centeral, California , USA, 12/04/2014 :الملخص
      Glimepiride and sildenafil citrate are metabolized in liver by cytochrome p450, and there is a possibility of drug interactions if they are taken together. Therefore, a simple and sensitive method for simultaneous determination and validation of sildenafil with glimepiride in rat plasma has been developed by using high performance liquid chromatography–mass spectrometry (HPLC-MS). A mixture of 70% methanol, 30% of 0.1% formic acid in water was used as a mobile phase, ACE 5 C18 column, the flow rate of 0.5 mL/min was used, the autosampler injection volume was 5 μL, and clarithromycin was used as an internal standard. The accuracy for glimepiride and sildenafil in all the three days of validation and all the four tested target concentration was 99.7% and 98.9% respectively. The standard curves for both drugs matched the requirements, linear relation (R2) ranged between; (0.994 to 1). The serum level of both drugs was lowered when combined together, in comparison Serum sildenafil level was affected by the combination to a greater extent than glimepiride. Sildenafil was found to decrease significantly when it is used in a combination (34.5 ng/mL) compared to solitary drug use (57.8 ng/mL). Download




      Wael Abu Dayyih, Lina Tamimi, Eyad Mallah,Nidal Qinna, Tawfiq Arafat, " Pioglitazone HCl Levels and Its Pharmacokinetic Application in Presence of Sucralose in Animals Serum by HPLC Method " , "Pharm Anal Acta ",Vol.5,No.(318)2, OMICS Group, California ,USA, 12/05/2014 :الملخص
      Purpose: to develop a simple, valid and rapid chromatographic method for quantifying pioglitazone HCl in rats serum in order to study the pharmacokinetic parameters of pioglitazone HCl in rats serum fed with sucralose simultaneously for examination of interaction possibility between pioglitazone HCl and sucralose in rats. Methods: In our developed method of analysis, mobile phase was consisted of [51.50%] acetonitrile and [48.50%] 0.025 mM ammonium acetate with pH of 8, column of separation was C8 at temperature of 40°C using injection volume of 90 μl, mobile phase flow rate was 1 ml/min and samples run time was 10 min, the signals were monitored and analyzed at λ=269 nm and sildenafil citrate was used as internal standard. Pioglitazone was given to rats orally of [10mg/kg] dose while sucralose was given with [11 mg/kg/day] dose. Results: A successful HPLC method was validated and developed to quantify pioglitazone HCl in rats serum, overall intra-day precision and accuracy were reasonable with CV % values range [0.16-3.54] and accuracy % range [ 98.4-107.9], while inter-day precision and accuracy showed accepted precision with CV% range [ 0.15- 4.13] and accuracy % range [99.35-103.99]. The coefficient of correlation was 0.9991 with reasonable sensitivity and selectivity. Combination effect of pioglitazone with sucralose on pioglitazone serum profile was demonstrated as strong statistical effect according to Cohen’s d and significant P values too. Conclusion: A successful HPLC method was validated and developed to quantify pioglitazone HCl in rats serum, combination effect of pioglitazone with sucralose over all time intervals of pioglitazone serum profile was demonstrated as strong statistical effect. Download




      Teeba Al. Shaikhli ,, " Determination of Atorvastatin Pharmacokinetic Parameters by LC/MS-MS with Traditional Liquorice Beverage " , "Advances in Analytical Chemistry",Vol.5,No.1, Scientific & Academic Publishing Co, USA, 01/05/2015 :الملخص
      The objective of this randomized controlled study was firstly, developing and validating a simple and simultaneous LC/MS method to quantify Atorvastatin in rat serum. Secondly, investigating the effects of Liquorice fresh beverage on the pharmacokinetics of Atorvastatin in serum rats. Atorvastatin was determined in rat's plasma using high resolution, sensitivity and validated Liquid Chromatography–Mass Spectrometry (LC-MS); The mobile phase was (75% methanol, 25% of 0.2% Formic acid in water), ACE 5 C8 Column (50 X 2.1 mm, 5µ), 1.0 ml/min flow rate, 5 microliters Autosampler injection volume, and Glimepiride as an internal standard. The analytical method was linear with acceptable recovery, precision and accuracy. A significant (P<0.05) effect of single dose of Liquorice after 2 hours from administration of Atorvastatin, and significant effect of repeated doses of Liquorice after 6 hours from administration of Atorvastatin. There was no significant effect (P>0.05) of single dose Liquorice juice on Atorvastatin Cmax (29.847 ng/ml), and repeated doses of Liquorice the Cmax was (40.113 ng/ml) which is also considered as a non- significant effect (P>0.05) We conclude that the effects of Liquorice beverage on Atorvastatin varies between single and repeated doses and this can be a result and could affect Atorvastatin pharmacokinetics. Keywords: Liquorice, Atorvastatin, LC/MS. Rat Plasma, Validation, Pharmacokinetic Download




      Riad Awad, Eyad Mall, " Determination of Hydrolysis Parameters of Yohimbine HCl at Neutral and Slightly Acidic Medium " , "International Journal of Pharmacy and Pharmaceutical Sciences",Vol.5,No.7, , India, 05/03/2015 :الملخص
      Objectives: In the process of investigating various new drug delivery systems of yohimbine HCl (Yoh), it was necessary to study some of the physical chemical properties of the drug including its stability at neutral, acidic and slightly acidic conditions. Methods: A validated HPLC method was developed and employed for analysis of Yoh containing solutions. The mobile phase composed of 60% menthol: 40% NaOAc (%v/v), and Gemi C18 column, 5 µm particle size was used as a stationary phase. The degradation product was found to be yohimbinic acid (YA). The retention times for Yoh and YA were 5 and 3 minutes, respectively. This study investigated the kinetics of hydrolysis of Yoh at pH 6.0 and 7.0 at temperatures from 50 °C to 80 °C. Results: The reaction followed first order kinetics and the activation energy ∆E of the reaction at pH 6 and pH 7 was found to be 16.2 and 16.8 Kcal. mole-1, respectively. While the values of A were found to be 41.8 and 44.1 Kcal. mole-1 at pH 6 and 7, respectively. The pseudo first order rate constants (K) at pH 6 and 7 were calculated as 2.76 х 10 -3 h-1 and 3.42 х 10 -3 h-1, respectively. Conclusion: Such results indicate high stability of the drug at these pH values. At highly acidic medium the reaction was found to be extremely slow indicating the absence of acid catalysis on the hydrolysis of Yoh. Thus, the yohimbine ester group resists hydrolysis in highly acidic conditions. Keywords: Yohimbine HCl, Yohimbinic acid, Stability, pH, Hydrolysis, Kinetic, Activation, Energ Download




      WAEL ABU DAYYIH, LIN, " Saxagliptin Levels and its Pharmacokinetic Application in Presence of Sucralose in Animals Serum by HPLC Method " , "International Journal of Pharmacy and Pharmaceutical Sciences",Vol.7,No.9, Innovare Academic Sciences, USA-India, 09/01/2015 :الملخص
      Objective: It is to develop a simple, valid and rapid chromatographic method for quantification of saxagliptin in rats serum in order to study saxagliptin pharmacokinetics parameters in sucralose fed rats simultaneously to detect any interaction possibility between saxagliptin and sucralose in rats. Methods: In our developed method of analysis, mobile phase was consisted of phosphate buffer (pH =4) and methanol (70:30) v/v at flow rate of 1 ml/min with UV detection at 230 nm., C8 column of separation was used with the temperature of 40 °C using injection volume of 50 µl, samples run time was 10 min, and sildenafil citrate was used as internal standard. Saxagliptin was given to rats orally of (2g/kg) dose while sucralose was given with (11 mg/kg/day) dose. Results: A successful HPLC method was validated and developed to determine saxagliptin in rats serum, overall intra-day precision and accuracy were reasonable with coefficient of variation percentage CV % values range (o.14-4.03) and accuracy % range (99.5-104), while inter-day precision and accuracy showed accepted precision with CV% range (0.15-2.81) and accuracy % range (99.9-116). The coefficient of correlation was 0.99949 with reasonable sensitivity and selectivity. Combination effect of saxagliptin with sucralose on saxagliptin serum profile was demonstrated as strong statistical effect according to Cohen’s d and significant P values too. Conclusion: A successful HPLC method was validated and developed to quantify saxagliptin in rats serum, combination effect of saxagliptin with sucralose over all time intervals of saxagliptin serum profile was demonstrated as strong statistical effect. Keywords: HPLC, Saxagliptin, Sucralose, Pharmacokinetic, Interaction. Download




      Eyad Mallah, Basel Arafat, Ahmad Abu Awwad, Wael Abu Dayyih, Mohammed Mima and Tawfiq Arafat, " Comparative bioavailability of two different quetiapine doses (50 and 200 mg) in healthy volunteers by using LC/MS method " , "Journal of Chemical and Pharmaceutical Research",Vol.6,No.12, , UK, 01/01/2015 :الملخص
      A selective, sensitive, stable and rugged high performance liquid chromatography tandem mass spectrometric method was developed and validated for determination Quetiapine in human plasma, then successfully applied in pharmacokinetic study for two different tablet doses of quetiapine (50 and 200) mg. The mobile phase consisting of (70% methanol: 30% water), pH=3.0. The method was validated according to European guideline for its linearity, accuracy, precision, selectivity, recovery and various stabilities. The standard curve was linear over a concentration range of (2.25-500.0) ng/ml, R2 was 0.999 and CV% of intraday accuracy and precision for the validation of QC samples was ranged between (1.82-3.61) %. A randomized, double-blind, two periods crossover full study was designed to investigate two different tablet doses from Quetiapine (50 and 200) mg. 40 healthy male volunteers were participated in this study, and the oral administration was occurred after overnight fasting. Blood samples were withdrawn from each subject at different time intervals and analyzed for Quetiapine concentrations. The pharmacokinetic parameters were performed and show that the maximum time of absorption (T max) for both doses was the same at 4.5 hr. The maximal plasma concentrations were (49.058 and 262.355) ng/ml and the Kel (0.07993 and 0.09207) for the (50 and 200) mg doses, respectively. However, based on these statistical data, quetiapine low and high doses were well tolerated and an obvious significant variation (p value less than 0.05) was found between them in human plasma. Key words: Quetiapine, bioavailability, LC/MS, human plasma. Download




      Eyad Mallah,Ahmed Al-Sheikh, Kamal Sweidan, Wael Abu Dayyih and Manfred Steimann, " Crystal structure of 5-[bis(methylsulfonyl) methyl]-1,3-dimethyl-5-(methylsulfonyl) pyrimidine-2,4,6(1H,3H,5H)-trione " , "Acta Cryst",Vol.E71,No.E71, Cross Mark, Germany, 12/16/2014 :الملخص
      In the title compound, C10H16N2O9S3, the pyrimidine ring of the 1,3-dimethyl barbituric acid moiety has an envelope conformation with the C atom carrying the methylsulfonyl and bis(methylsulfonyl)methyl substituents as the flap. The dihedral angle between mean plane of the pyrimidine ring and the S/C/S plane is 72.4 (3). In the crystal, molecules are linked via C—H  O hydrogen bonds, forming a threedimensional structure. Download




      Mallah E, Arafat B, Al khawaja B, Abu Dayyih W, Abu Awad A, Hroub HA, Hamad M and Arafat T , " Relative Bioavailability of Ciprofloxacin Doses (750 and 1000) mg in Healthy Male Volunteers by Using HPLC Method " , "Journal of Bioequivalence Studies",Vol.1,No.1, Annex Publishers | www.annexpublishers.com, USA, 01/01/2015 :الملخص
      Abstract A new, stable and accurate high performance liquid chromatography ultraviolet spectrophotometric method for quantitation of Ciprofloxacin in human plasma was developed and validated. The chromatographic separation was performed on a reversed phase BDS (base deactivated silica) C18 analytical column; 150 × 4.6; 5 μm particle size. The mobile phase consisted of a mixture of 1 ml triethylamine (TEA)/1L, water and acetonitrile (80:20 v/v). The pH of mobile phase was adjusted to 2.5 by using phosphoric acid and the detector was set at a wavelength of 280 nm. Accuracy, precision, linearity and stability of the analytical method were done. The regression equations are linear (R2 was 0.999) over the calibration curve concentration range of (0.10-8.0) μg/ml. Inter and Intra precision (% CV) were less than 6.102% and 6.82% respectively. Keywords: Ciprofloxacin; Bioavailability; HPLC; Pharmacokinetic; Validation Two different tablet doses of Ciprofloxacin (750 and 1000) mg were administrated to 28 healthymalevolunteers in cross over design, blood samples were taken from the participant at different time intervals andthen Ciprofloxacin concentrations were analyzed. The bioavailability and pharmacokinetic parameters were calculated, the maximum absorption time (t max) was equal for both doses (3.0hr). The maximum concentrations (Cmax) were (1.93 and 2.45) μg/ml for the (750 and 1000) mg doses, respectively. Regarding area under the curve (AUC) for 750 and 1000 mg doses were found (15.30 and 19.12 μg*t/ml), respectively. Obviously, thevariation was significantly found in Ciprofloxacin doses (p value less than 0.05) and the pharmacokinetic data confirm the relative trend of bioavailability and absorption of Ciprofloxacin in human plasma Download




      Sally Oumeish , Eyad Mallah, Wael Abu Dayyih , Mohammed Hamad , Walid Abu Rayyan , Mona Bustami and Tawfiq Arafat, " Serum concentrations of magnesium among Jordanians: Effect of cardiovascular disease on magnesium levels " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., www.jocpr.com, , 12/01/2015 :الملخص
      Magnesium plays a role in a numerous enzymatic reactions such as; it fulfils various intracellular physiological functions. Therefore, irregularity in magnesium status-mainly hypomagnesaemia as it is seen more often than hypomagnesaemia—might result in unwanted neuromuscular, cardiac or nervous di Download




      Moh'd Salemaldajeh , Eyad Mallah, Riad Awad , Wael Abu Dayyih , Feras Darwish Elhajji , Israa H. Al-ani , Basmah A. Othman and Tawfiq Arafat, " Determination of carbamazepine in rat plasma in the presence of licorice juice by using HPLC and its pharmacokinetic applications " , "Journal of Chemical and Pharmaceutical Research",Vol.,No., www.jocpr.com , , 12/31/2015 :الملخص
      Carbamazepine (CBZ) is the first choice anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. A simple, rapid a nd accurate method for determination of carbamazepi ne in rat plasma in presence of licorice has been developed by using High perform Download




      Wael A. Abu Dayyih, Eyad M.Mallah, Israa H.Al-Ani, Tawfiq A. Arafat, " Liquorice Beverage Effect ton the Pharmacokinetic Parameters of Atorvastatin,Simvastatin,and Lovastatin by Liquid Chromatography -Mass Spectroscpy/LC-MS/MS " , "Asian Journal of Pharmacy and Clinical Research",Vol.,No., Annovare Academics, , 03/14/2016 :الملخص
      Objective: The objective of this study is to examine the effects of pre-consumption of freshly prepared liquorice beverage (4 ml/kg) on the pharmacokinetic (PK) parameters of (80 mg/kg) oral dose of atorvastatin, simvastatin, and lovastatin in healthy rats plasma. Methods: A simple, rapid, and app Download




      Hanan Al-Horani, Wael Abu Dayyih, Eyad Mallah, Mohammed Hamad, Mohammad Mima,Riad Awad, and Tawfiq Arafat1, " Nationality, Gender, Age, and Body Mass Index Influences on Vitamin D Concentration among Elderly Patients and Young Iraqi and Jordanian in Jordan " , "Biochemistry Research International",Vol.,No., Hindawi Publishing Corporation, , 03/25/2016 :الملخص
      Vitamin D is necessary for maintaining and regulating calcium levels; thus, insufficiency of vitamin D increases the risk of many chronic diseases. This study aimed to examine vitamin D levels among Jordanian and Iraqi volunteers and find the relation between vitamin D level and lipid profile patien Download




      Ahmed Al-Kawaz , Wael Abu Dayyih*, Eyad Mallah , Mohammed Hamad , Tawfiq Arafat, " (A STUDY OF THE POSSIBLE EFFECT OF POMEGRANATE JUICE ON THE PHARMACOKINATICS OF CANDESARTAN IN RAT PLASMA BY USING A BIOANALYTICAL METHOD- LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY (HPLC/MS/MS " , "International Journal Of Pharmacy & Technology ",Vol.,No., http://www.ijptonline.com/, , 03/31/2016 :الملخص
      Background: drug interactions with fruit juices (beverages) have received considerable attention from basic scientists, physicians, and industry and drug regulatory agencies. The aim of this study is to develop a new simple, rapid and sensitive method for validation and determination of candesarta Download




      Mohammed Hamad , Ahmed Al-Sharqawi , Wael Abu Dayyih*, Eyad Mallah , Tawfiq Arafat, " Simultaneous estimation of Esomeprazole and Tadalafil in pharmaceutical formulations using High Performance Liquid Chromatography " , "Journal of Applied Pharmaceutical Science",Vol.,No., (JAPS), , 04/30/2016 :الملخص
      An easily, specific, precise, and accurate reversed-phase HPLC method was developed and validated for simultaneous estimation of esomeprazole ( Nexium® ) and tadalafil (Cialis® ) in pharmaceutical formulation. The separation was achieved by using Hypersil BDS C18 column (250 mm × 4.6 mm; 5.0 μm) Download




      Eyad M. MALLAH , Walid S.A. RAYYAN , Wael A.A. DAYYIH , Feras D. ELHAJJI, Kenza A. MANSOUR , Ibrahim S. AL-MAJALI & Tawfiq A. ARAFAT, " Dose-Dependent Synergistic effect of Pomegranate Juice on the Bioavailability of Sildenafil in Rats by Using HPLC Method " , "Latin American Journal of Pharmacy (formerly Acta Farmacéutica Bonaerense)",Vol.,No., Acta Farmacéutica Bonaerense, , 07/20/2016 :الملخص
      SUMMARY. World widely, the prevalence of erection dysfunction (ED) ranged from 2% in men younger than 40 years to 86% in men 80 years or older. Sildenafil citrate. a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP), is widely prescribed for ED treatment. Pomegranate (Punica Download




      Awad R, Mallah E, Khawaja BA, Dayyih WA, El-Hajji F, Matalka KZ, Arafat T., " Pomegranate and licorice juices modulate metformin pharmacokinetics in rats " , " Neuroendocrinology Letters",Vol.,No., Neuroendocrinology Letters since 1997, , 07/15/2016 :الملخص
      OBJECTIVES: Food or drinks may significantly alter the pharmacokinetics and pharmacodynamics of drugs which may lead to adverse events. A drug such as metformin is widely used to regulate plasma glucose level and pomegranate and licorice have been identified to help in type-2 diabetes management. H




      Riad Awad, Eyad Mallah , Israa Al-Ani , Wael Abu Dayyih, Zainab Zakarya , Tawfiq Arafat, " Investigation of possible pharmacokinetic interaction of metformin with sugar replacement sweeteners in rats " , "Journal of Applied Pharmaceutical Science",Vol.,No., Journal of Applied Pharmaceutical Science , , 10/31/2016 :الملخص
      Metformin is widely used for type II diabetes. Sugar replacement sweeteners such as Aspartame and Stevia, are usually consumed concomitantly with other antidiabetics by patients The aim of this work is to investigate possible effects of two types of sweeteners; stevia and aspartame on the pharmaco Download




      DeKamal Sweidan, Wael Abu Dayyih, Murad A. AlDamen, Eyad Mallah, Tawfiq Arafat, Mustafa M. El-Abadelah, Hanadi Salih and Wolfgang Voelter*, " Ring opening of cyclobutane in 1,3-dimethyl- 5-methylenebarbituric acid dimer by various nucleophiles " , "DE GRUYTER",Vol.,No., De Gruyter Publisher, , 02/15/2017 :الملخص
      Abstract: The reactivity of cyclobutane moiety in 1,3-dimethyl-5-methylenebarbituric acid dimer (5) towards different nucleophiles was investigated. New derivatives of 5-(substituted methyl)-1,3-dimethylbarbiturate 6–13 were prepared in good yields using various aliphatic amines, cyanide anion, Download




      Wael Abu Dayyih, Mohammed Hamad, Ahmad Abu Awwad,Eyad Mallah, Zainab Zakarya, Alice Abu Dayyih, and Tawfiq Arafat, " A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers " , "Journal of Analytical Methods in Chemistry",Vol.,No., Hindawi, , 08/15/2017 :الملخص
      Enalapril is an angiotensin-converting enzyme inhibitor used for treatment of hypertension and chronic heart disease. Enalaprilat is its active metabolite responsible for the activity. This study aimed to develop and validate a method for enalapril and enalaprilat analysis and to determine the bioeq Download




      Mohammed Mima, Eyad Mallah, Wael Abudayyih, Feras D Elhajji, Hanadi Salih, Zainab Zakaraya, Basmah Othman, Tawfiq Arafat, " Pharmacokinetics and Pharmacodynamics Interaction of Warfarin in the Presence of Beverage Juices (Licorice and Pomegranate) in Rat Plasma by Using LC/MS " , "LATIN AMERICAN JOURNAL OF PHARMACY",Vol.,No., Argentina, , 01/01/2017 :الملخص
      Warfarin, a coumarin derivative vitamin K antagonist, as a narrow therapeutic drug, it requires deep monitoring especially with various drugs, food and even juices. This study was set with the aim of investigation the impact of pomegranate and licorice juices on both pharmacokinetics and pharmacodyn




      Wael Abudayyih and Khalid Matalka Kenza Mansoor , Fadi Qadan , Mathias Schmidt , Eyad Mallah, " Stability Study and a 14-Day Oral Dose Toxicity in Rats of Plantain Leaf Extract (Plantago lanceolata L.) Syrup " , "Scientia Pharmaceutica",Vol.,No., Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG, , 03/22/2017 :الملخص
      Plants have been used since antiquity to treat and prevent diseases. Plantain (Plantago lanceolata L.) is traditionally used for the treatment of the common cold and associated symptoms such as cough. This study was designed to evaluate the oral toxicity of plantain leaf extract-containing syrup. In




      Tawfiq Arafat Eyad Mallah, Soadad Saleh, Walid Abu Rayyan, Wael Abu Dayyih, Feras Darwish Elhajji , Mohammed Mima, Riad Awad, " The influence of Eruca sativa (Arugula) on pharmacokinetics of Sildenafil in rats " , "Neuroendocrinology Letters",Vol.,No., Maghira and Maas Publications, , 09/05/2017 :الملخص
      Abstract OBJECTIVES: A drug like Sildenafil is commonly used for the treatment of erectile dysfunction. Eruca sativa is known as a garden plant used in folk medicine to enhance the sexual desire in males. Nevertheless, the interaction of Sildenafil and Eruca sativa was not studied. In the current st Download




      HAMAD M, AL-JARIRI R, AL TAMIMI L, ABU DAYYIH A, ABU DAYYIH W*, MALLAH E, AND ARAFAT T, " Validation and Determination of Piracetam in Rat Plasma by Using High Performance Liquid Chromatography /UV/VIS Spectrometry (HPLC/UV/VIS) in Presence of Pomegranate and Liquorice Juices for Pharmacokinetics Study " , " International Journal of Biology, Pharmacy and Allied Sciences (IJBPAS)",Vol.,No., BPAS PUBLISHERS LLP , , 12/01/2017 :الملخص
      The study aimed to develop a simple and rapid chromatographic method for quantifying piracetam in rat plasma and study the pharmacokinetic parameters with and without pomegranate and liquorice juices. A new validated, simple and rapid method for determination of piracetam in presence of pomegran Download




      Wael Abu Dayyih et.al, " The Effect of some Fruit Juices on Glimepiride Pharmacokinetic in Rat Plasma by using High Performance Liquid Chromatography-Mass Spectrometry " , "Biomedical and Pharmacology Journal",Vol.,No., Oriental Scientific Pub.Co, , 12/31/2017 :الملخص
      Food-drug interactions may affect pharmacokinetics or pharmacodynamics of a drug. Failure to identify and properly manage drug-nutrient interactions may lead to serious consequences. In this study, we try to develop and validate a simple and sensitive analytical method for measuring of glimep




      Wael Abu Dayyih, Mohammed Hamad, Eyad Mallah, Alice Abu Dayyih, Kenza Mansour, Zainab Zakarya, Riad Awad,T, " Establishment and Validation of a Sensitive Method for Detection of Pregabalin in Pharmacological Formulation by GC/MS Spectrometry " , "Current Pharmaceutical Analysis",Vol.,No., Bentham Science Publishers, , 12/31/2017 :الملخص
      Abstract: Background: A gas chromatography and mass spectrometry (GC/MS) procedure was developed and validated for the evaluation and quantification of pregabalin (PGN) in pharmaceutical preparations. Introduction: Pregabalin is γ-amino-n-butyric acid derivative used as an antiepileptic drug, fo




      , Wael A. Abu Dayyih,Mohammed F. Hamad, " Evaluated Method For The Separation And Identification Of Paracetamol Impurities By Reverse Phase High Performance Liquid Chromatography " , "International Journal of Biology, Pharmacy and Allied Sciences",Vol.,No., BP PUBL, LUCKNOW, , 03/30/2018 :الملخص
      Paracetamol is used as pain and fever treatment and listed as the most important medication needed in the basic health system. This study was established to separate paracetamol and some impurities from a mixture using high performance liquid chromatography (HPLC) via Ultra Violet (UV) detection.




      Wael Abu Dayyih , Zainab Zakarya , Alice Abu Dayyih,Israa Al-Ani, " Reversed Phase HPLC for a Validation and Determination of Udenafil (Zydena® ) and Dapoxetine (Priligy® ) Simultaneously in Tablet Dosage Form in Jordanian M " , "Der Pharma Chemica",Vol.,No., Scholars Research Library , , 03/28/2018 :الملخص
      Scholars Research Library




      Ghaleb Oriquat and Samira F. Hassan Saif S. Abbas, Israa H. Al-Ani, Wael A. Abu Dayyih, " Investigation of Possible Pharmacokinetic Interaction Between Ivabradine and Carvedilol in Rats using High Performance Liquid Chromatography/Mass Spectroscopy " , "Biomedical and Pharmacology Journal",Vol.,No., Oriental Scientific Pub. Co., , 03/31/2018 :الملخص
      Ivabradine is a new hyperpolarization-activated cyclic nucleotide-gated channel (HCN) blocker. It has been approved by the FDA in 2015 as a part of management of stable angina and congestive heart failure. The aim of this study was to investigate the possibility of pharmacokinetic interaction of a p




      Luay Abu Qatoosah and Tawfiq Arafat Eyad Mallah, Walid Abu Rayyan, Wael Abu Dayyih, Ibrahim S. Al-Majali, Haitham Qaralleh, Osama Yosef Al- Thunibat, Nisreen Seder, Mona Bustami, " Analytical and Comparative Study About the Impact of Lead Homeostasis on Cardiovascular Disorders in Humans " , "Biomedical and Pharmacology Journal",Vol.,No., Oriental Scientific Pub. Co, , 03/30/2018 :الملخص
      World health organization reported cardiovascular disease as the first cause of mortality for five consecutive years of 2010-2014. Smoking is an exogenous source of metals contamination in the human body and attributed to 12% of all deaths among adults aged over 30 years. This is the first study car




      Mohammed F Hamad, Wael A Abu Dayyih, Mohammad Laqqan, Yasir AlKhaled, Mathias Montenarh, Mohammed E Hammadeh, " The status of global DNA methylation in the spermatozoa of smokers and non-smokers " , "Reproductive BioMedicine Online",Vol.,No., Elsevier, , 10/06/2018 :الملخص
      Abstract Research question Does regular smoking affect semen quality and the levels of DNA methylation in mature human spermatozoa? Design Spermatozoa from 109 men were evaluated (55 smokers and 54 non-smokers). DNA was extracted from purified spermatozoa, and DNA methylation was quantified by




      Mohammed F Hamad, Wael A Abu Dayyih, Mohammad Laqqan, Yasir AlKhaled, Mathias Montenarh, Mohammed E Hammadeh, " The status of global DNA methylation in the spermatozoa of smokers and non-smokers " , "Reproductive BioMedicine Online",Vol.,No., Elsevier, , 10/06/2018 :الملخص
      Abstract Research question Does regular smoking affect semen quality and the levels of DNA methylation in mature human spermatozoa? Design Spermatozoa from 109 men were evaluated (55 smokers and 54 non-smokers). DNA was extracted from purified spermatozoa, and DNA methylation was quantified by




      Nisreen Seder and Tawfiq Arafat Mohammad Abdulla, Eyad Mallah, Wael Abu Dayyih, Walid Abu Rayyan, Feras Darwish El-Hajji, Mona Bustami, Kenza Mansour, Israa Al-Ani, " Influence of Energy Drinks on Pharmacokinetic Parameters of Sildenafil in Rats " , "Biomedical and Pharmacology Journal",Vol.,No., Oriental Scientific Pub. Co, , 09/30/2018




      Nisreen Seder and Tawfiq Arafat Mohammad Abdulla, Eyad Mallah, Wael Abu Dayyih, Walid Abu Rayyan, Feras Darwish El-Hajji, Mona Bustami, Kenza Mansour, Israa Al-Ani, " Influence of Energy Drinks on Pharmacokinetic Parameters of Sildenafil in Rats " , "Biomedical and Pharmacology Journal",Vol.,No., Oriental Scientific Pub. Co, , 09/30/2018




      T. ARAFAT, W. ABU DAYYIH*, M. HAMAD, E. MALLAH, A., R. AWAD, Z. ZAKARIA, " Method Development And Validation of Vildagliptin and Metformin HCL in Pharmaceutical Dosage Form by Reversed Phase–High Performance Liquid Chromatography (RP-HPLC) " , "International Journal of Pharmaceutical Sciences and Research",Vol.,No., Society of Pharmaceutical Sciences and Research, , 07/01/2018 :الملخص
      ABSTRACT: Determination of the anti-diabetic drugs vildagliptin and metformin is wildly used to validate drug efficiency in diabetic patients. Here we describe a new and simple chromatographic method to analyze both drugs simultaneously in their commercial pharmaceutical dosage forms. A reverse




      Tawfiq Arafat , Areej Rahhal, Wael Abu Dayyih*, Eyad Mallah, Alice Abu Dayyih, Zainab Zakaria and Mohammed Hamad, " Development and Validation of Liquid Chromatography Method for Determination of Glimepiride in Presence of (Vimto®) Soft Drinks in Rats: o Application to Pharmacokinetics Studies " , "Journal of Pharmacy and Bioallied Sciences",Vol.11,No., Medknow Publications and Media Pvt. Ltd, 1, 02/12/2019 :الملخص
      Context: Diet and beverages are thought to have notable effects on drugs. Recently, this relationship has received significant consideration. Aims: To develop and validate a simple, rapid, and sensitive method for the determination of glimepiride in rat serum. This will be performed using high-pe




      Alhuda ALANBAKI , Israa ALANI, Zainab ZAKAREIA, Tawfiq ARAFAT, Wael ABU DAYYIH, " The effect of Pomegranate and Licorice on Pharmacokinetics of Theophylline in Rat Plasma " , "FABAD-Journal of Pharmaceutical Sciences",Vol.44(1),No., Ayşegül KÖROĞLU, ANKARA, 04/01/2019 :الملخص
      Food or drinks may significantly alter the pharmacokinetics and pharmacodynamics of drugs which may lead to adverse events. A drug such as theophylline is widely used to treat asthma and chronic obstructive pulmonary disease. Pomegranate and licorice have been identified to help in cough managem Download




      AMERA ABUDAHER, ZAINAB ZAKAREIA , EYAD MALLAH , WAEL ABU DAYYIH , TAWFIQ ARAFAT , AND LUAY ABU-QATOUSEH, " HYPOGLYCEMIC EFFECT OF OLIVE OIL ON PATIENTS AND HEALTHY INDIVIDUALS IN JORDAN " , "International Journal of Biology, Pharmacy and Allied Sciences (IJBPAS)",Vol.8,No., Medknow Publications and Media Pvt. Ltd, India, 08/01/2019 :الملخص
      Dyslipidemia and DM are groups of metabolic disorders which constitute major health problems worldwide. EVOO has been used in a folk medicine to treat diabetes, which have a potent effect in decreasing glucose level, triglyceride, cholesterol, LDL, and increased HDL, which studied previously. E




      LAYALI ABU ALADASS , EYAD MALLAH, MOHAMMED HAMAD , WAEL ABU DAYYIH , DA'SAN M. M. JARADAT, NASIR M IDKAIDEK , SOADAD SALEH , LUAY ABU-QATOUSEH , MONA BUSTAMI , YAHYA H. F. ALQUDAH , TAWFIQ ARAFAT, " FACTORS AFFECTING COENZYME COBALAMIN (VITAMIN B12) LEVELS IN HEALTHY AND PATIENT INDIVIDUALS FROM PETRA REGION (JORDAN) " , "International Journal of Biology, Pharmacy and Allied Sciences (IJBPAS)",Vol.8,No., Medknow Publications and Media Pvt. Ltd, India, 08/01/2019 :الملخص
      The aim of this study was to investigate levels of vitamin B12 deficiency in healthy and patient individuals in Petra region in Jordan. The study was designed to include different subject groups based on different factors including gender, age, body mass index (BMI), diet, smoking, and disease (d


  • Conference paper





      , " Management and treatment of solid wastes .Biogas as renewable energy; mechanism of production from Al Rusaifa Landfill. " , "",Vol.,No., , , 04/21/2008 :الملخص
      mechanism of treatment and mangment of solid wastes and transfering the biogass to electricity /Rusaifa landfill




      , " Selective electrodes for determination of acetylsalicylate anion in aspirin " , "",Vol.,No., , , 08/20/2007 :الملخص
      Study of acetylsalicylate anion in aspirin, by a new type of selective electrodes based in plynuclear compound




      Wael Abu Dayyih , Eyad Mallah , " Pomegranate and Licorice Juices ModulateMetformin Pharmacokinetics in Rats " , "International Congress and Exhibition on Pharmacy-DUBAI 2017",Vol.,No., Scientific Federation, , 04/03/2017


  • Web





      Wael Abu Dayyih, " https://scholar.google.com/citations?user=JmsJjLAAAAAJ&hl=en " , "https://scholar.google.com/citations?user=JmsJjLAAAAAJ&hl=en",Vol.,No., Google Scholar, , 12/12/2015 :الملخص
      https://scholar.google.com/citations?user=JmsJjLAAAAAJ&hl=en




      Wael Abu Dayyih, " https://www.researchgate.net/profile/Wael_Abu_Dayyih " , "Researchgate",Vol.,No., Researchgate, , 12/12/2015 :الملخص
      https://www.researchgate.net/profile/Wael_Abu_Dayyih
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